Hello,
It is easy to spread virus through pendrive ,
Precautions .
Press shift key when u connect pendive to your system. This will kill the autorun action.
Then open mycomputer and rightclick on the drive icon and select explore.
copy or paste the content and remove it
And two other way from my friend SuperLolek
hmm well.. there are other ways:
1) disable autorun globally,
2) use other than windows, operating system 
By superlolek, 4. August 2008
me : yeay its me arun